This introduction begins with the expansion of the field of semiotics and continues with the relationship between semiotics and epistemology before presenting the articles that make up this special issue of the journal Syn-Thèses. The content and transmutation of sign and its information through the conversation of the sciences has been a challenge for a number of scholars who have studied it in different research settings and through different semiotic theories, enriching our knowledge as readers and advancing one of the most important issues of our time: the conversation of the sciences and how it can help people and the advancement of science