Parasitic weeds are a major threat to food security in Africa and control measures mostly done by smallholder farmers are not effective in eradicating the parasites. This results in a yield loss up to 100%. Parasitic weeds comprise Alectra vogelii, Striga spp., Orobanche spp., Rafflesia spp., and Phoradendron spp. Parasitic attachment is successful when three necessary conditions have been fulfilled namely the compatible host, suitable environment, and parasitic weed. These species parasite plant species through special attachment features such as modified leaves, suckers, haustoria, or modified roots. In Africa, the variability of parasitic weeds is largely driven by environmental factors such as temperature, rainfall, soil type, and crop husbandry practices. Warmer temperatures create more hospitable conditions for certain parasitic weeds, and allowing them to spread to new areas. Parasitic weed control is vital for effective crop production and the control strategies can be achieved through integrated weed control method that embraces mechanical, cultural, chemical, and biological methods. However, the most effective and crucial method is the cultivation of resistant varieties that provide long-term protection against parasitic weeds. Studies have been done on host-parasite attachment where dodder can send out new roots to infected neighbouring plants and spread their parasitic behaviour. More insight and knowledge should offer new goals for control within the life cycle of the parasitic weeds and their metabolic activities. Lastly, disciplines such as agronomy, plant breeding, nutrition, economics, and IT should play their roles effectively in combating parasitic weeds