Purpose: The study aimed to assess the incidence of and risk
factors leading to visual impairment and legal blindness in
children with retinoblastoma. Procedures: This is a singlecenter, retrospective case series of all patients with bilateral
retinoblastoma presenting from 2010 to 2014. Results: A total of 44 patients were included in the study. Visual impairment was present in 14 (38%) children, legal blindness was
present in 7 (19%) children. Bilateral macular tumors (BMT)
were associated with visual impairment (12 of 18 patients
with BMT, 2 of 19 patients without BMT, p = 0.0006) and legal
blindness (7 of 18 patients with BMT, 0 of 19 patients without
BMT, p = 0.003).The International Intraocular Retinoblastoma Classification (IIRC) of the better eye also predicted visual impairment (16% in IIRC Group A–C, 75% in IIRC Group
D, E, p = 0.004) and blindness (3% eye in IIRC Group A–C, 50%
in Group D, E, p = 0.005). Various non-Snellen visual acuity
measures were able to predict visual impairment in pre-verbal children, providing them with early assistance. Conclusions: The rates of visual impairment and blindness reported
in this paper can be used to counsel families regarding the
risk of binocular visual impairment. Early detection and support for visually impaired infants are essential as d