Conway, GS

Davies, MC

Elliott, J

La Rosa, C

Nair, S

Pimblett, A

Wilson, J

English

UCL Discovery

28/11/2021, 23:17Risk of bone fracture is not increased in women with TS compared …S2018 | Society for Endocrinology BES 2018 | Endocrine AbstractsPage 1 of 2https://www.endocrine-abstracts.org/ea/0059/ea0059p054Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online) Endocrine AbstractsEndocrine Abstracts (2018) 59 P054 | DOI: 10.1530/endoabs.59.P054! 8 viewsAuthor affiliationsWomen with Turners Syndrome (TS) have been shown to have reduced bone mineraldensity (BMD) but there is uncertainty about how this relates to fracture risk. The littledata that does exist is conflicting, with one case series finding no difference compared tocontrols and one survey suggesting an increased risk of fracture particularly of theforearm. Proposed mechanisms for reduced BMD include short stature, oestrogendeficiency and bone dysplasia. In addition, fracture risk might be related to hearingimpairment and propensity to falls. Here we investigate fracture risk factors in womenwith TS.Methods: Self reported fracture history was collected from 265 women with TS. Tocontrol for oestrogen deficiency we selected a control group of women with early onsetPremature Ovarian Insufficiency (POI) (n=42). Fracture risk variables included; age,height, hip and spine BMD, BMI, age of first oestrogen exposure and hearing aid use. Wealso compared fracture rates of the spine, arm, wrist, femur and foot.Results: Women with TS were older (31.3 vs 37.5years), diagnosed earlier (17.4 vs 9.6years) and shorter (1.66 vs 1.50 m). Spine BMD was lower in POI (t-score −1.4 vs −0.90,P<0.05) but not different for the hip (t-score −0.96 vs −0.77). There was no significantdifference in fracture rate 87/265(32.8%) vs 14/42(33.3%); P=0.9 or fracture sitebetween groups. Within the TS group, there was no difference in fracture risk variablesin those with a facture history compared to those without.P054  "  Section  #  Contents  Cite$  Prev Next %Bone and calciumRisk of bone fracture is not increased inwomen with TS compared to women withovarian failureAntoinette Pimblett , Jessica Elliot , Jack Wilson , Sasha Nair , Clementina La Rosa , Melanie C Davies  &Gerard S Conway1 1 1 2 2 21Facebook Twitter Email More PrintVolume 59Society for EndocrinologyBES 2018&  Glasgow, UK '  19 Nov 2018 - 21 Nov 2018Society for Endocrinology (Browse other volumes) *SummaryAbstractsProgrammeVolume EditorsAbstract BookEPostersArticle toolsSelect Language ​ ▼  | DisclaimerMy recent searchesNo recent searches.My recently viewedabstractsNo recent abstracts.Search Issues/Conferences Cite About Our Services Policies Contact Disclaimer +Search for abstract title, authors etc.28/11/2021, 23:17Risk of bone fracture is not increased in women with TS compared …S2018 | Society for Endocrinology BES 2018 | Endocrine AbstractsPage 2 of 2https://www.endocrine-abstracts.org/ea/0059/ea0059p054Conclusions: When compared to a similar oestrogen deficient group, women with TSappear not to have an increased rate of fracture. The results suggest that fracture risk inTS can be accounted for by oestrogen deficiency, rather than propensity to falls or bonedysplasia. BMD scans may not be a good surrogate marker of fracture risk in TS.AuthorsPimblett AntoinetteElliot JessicaWilson JackNair SashaLa Rosa ClementinaDavies Melanie CConway Gerard SEndocrine AbstractsISSN 1470-3947 (print) | ISSN 1479-6848(online)© Bioscientifica 2021 | Privacy policy | CookiesettingsBioscientifica Abstracts is the gateway to aseries of products that provide a permanent,citable record of abstracts for biomedical andlife science conferences.Find out moreWe place cookies on your device togive you the best experience of thiswebsite. If you don't change yourcookie settings, we'll assumeyou're happy with this.Yes,that’sfineChangesettingsI want moreinformation

Risk of bone fracture is not increased in women with TS compared to women with ovarian failure

https://discovery.ucl.ac.uk/10139271/1/2018%20BES%20Risk%20of%20fracture%20is%20not%20increased%20in%20women%20with%20TS%20compared%20to%20women%20with%20ovarian%20failure%20.pdf

Risk of bone fracture is not increased in women with TS compared to women with ovarian failure

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