Blázquez, Ana-Belén

Calvo-Pinilla, Eva

Casas, Josefina

Casasampere, Mireia

Escribano-Romero, Estela

Jiménez de Oya, Nereida

Martín-Acebes, Miguel A.

Mingo-Casas, Patricia

Pérez-Pérez, Maria-Jesús

Saiz, Juan-Carlos

San-Félix, Ana

English

Blázquez, Ana B.

Saiz Calahorra, Juan Carlos

Martín-Acebes, M. A.

Digital.CSIC

Synthetic polyphenols inhibit West Nile virus infection through alteration of sphingolipid metabolismSeptember 2022Conference: XVI Congreso Nacional de VirologiaAt: MálagaPolyphenols are promising lead compounds for new therapeutic agents as they can exert multiple pharmacological activities, including the alteration of lipid metabolism. The evaluation of our own collection of polyphenols against West Nile virus (WNV) led to the identification of two hits with significant antiviral activity and no toxicity. These compounds also inhibited the multiplication of other flaviviruses, exhibiting lower or undetectable antiviral activity against other non-related RNA viruses. The mechanism underlying their antiviral activity against WNV involved the alteration of sphingolipid metabolism. These results unveil the potential of novel antiviral strategies based on the modulation of the cellular levels of sphingolipids for the control of flavivirus infection.

Synthetic polyphenols inhibit West Nile virus infection through alteration ofsphingolipid metabolism

https://digital.csic.es/bitstream/10261/310929/1/Synthetic%20polyphenols%20inhibit%20West%20Nile%20virus%20infection%20through%20alteration%20of%20sphingolipid%20metabolism.docx

Synthetic polyphenols inhibit West Nile virus infection through alteration of
sphingolipid metabolism

Synthetic polyphenols inhibit West Nile virus infection through alteration of sphingolipid metabolism

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