Procédés et compositions pour le traitement de troubles caractérisés par un dysfonctionnement de KIDINS220 chez un sujet

Abstract

The present invention relates to retromer complex activators and compositions for use in the treatment and/or prevention of neurological and psychiatric disorders characterized by Kidins220 dysfunction in a subject. These disorders may be further characterized by ventriculomegaly and/or excitotoxicity. It also relates to methods for screening a retromer complex activator for use in the treatment and/or prevention of said disorders in a subject.NoConsejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Consorcio Centro de Investigación Biomédica En Red del Área de Enfermedades Neurodegenerativas (CIBERNED)A1 Solicitud de patente con informe sobre el estado de la técnic