EVANESCENT FIELD FLUORESCENCE DETECTION OF SPECIFIC AND NON-SPECIFIC BINDING OF INSULIN TO RECEPTORCONTAINING PLANAR BILAYERS SUPPORTED ON SUBSTRATES

Abstract

Binding of insulin to the receptor leads to a conformational change of the later which is accompanied by a change in lipid/protein interaction, This effect is expected to lead to a change in surface potential of the supported bilayer which could be exploited for biosensors