van der Sluis, O.

Verhoosel, C.V.

Willems, R.

English

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 NURBS-based isogeometric analysis of a bi-ventricular heartmodelCitation for published version (APA):Willems, R., Verhoosel, C. V., & van der Sluis, O. (2022). NURBS-based isogeometric analysis of a bi-ventricular heart model. Abstract from 8th European Congress on Computational Methods in Applied Sciencesand Engineering, ECCOMAS 2022, Oslo, Norway.Document status and date:Published: 01/06/2022Document Version:Author’s version before peer-reviewPlease check the document version of this publication:• A submitted manuscript is the version of the article upon submission and before peer-review. There can beimportant differences between the submitted version and the official published version of record. Peopleinterested in the research are advised to contact the author for the final version of the publication, or visit theDOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and pagenumbers.Link to publicationGeneral rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license above, pleasefollow below link for the End User Agreement:www.tue.nl/taverneTake down policyIf you believe that this document breaches copyright please contact us at:openaccess@tue.nlproviding details and we will investigate your claim.Download date: 17. Nov. 2023The 8th European Congress on Computational Methods in Applied Sciences and EngineeringECCOMAS Congress 20225-9 June 2022, Oslo, NorwayNURBS-BASED ISOGEOMETRIC ANALYSIS OF ABI-VENTRICULAR HEART MODELR. Willems1,∗, C.V. Verhoosel2 and O. van der Sluis2,31 Eindhoven University of Technology, Department of Biomedical Engineering,PO Box 513, 5600 MB, Eindhoven, The Netherlands, { r.willems@tue.nl }2 Eindhoven University of Technology, Department of Mechanical Engineering,{ c.v.verhoosel@tue.nl, o.v.d.sluis@tue.nl }3 Philips research, High Tech Campus, Eindhoven, The NetherlandsKeywords: Isogeometric analysis (IGA), Patient-specific analysis, NURBS geometry,Ventricular tachycardiasPatients suffering from Ventricular Tachycardias (VTs, a fast abnormal heart rate), re-quire ablation therapy to treat the scar tissue located on the left ventricle which causesVTs. Success rates are considered moderate (50-80%) and can be elevated using patient-specific three-dimensional computer models of the human heart, specifically the ventricles.Current electromechanical ventricular models using Finite Element Analysis (FEA) arecomputationally expensive, which is impractical for clinical applications. Furthermore,patient-specific FEA models rely on accurate input data to produce meaningful results.We propose an approach in which the Isogeometric Analysis (IGA) paradigm [1] is appliedto existing mechanical ventricular models subject to limited available input data. IGAenables the construction of smooth discretized geometries, which require fewer degrees offreedom, making them ideal for clinical applications.In this contribution, we present a method for constructing a template bi-ventricle NURBSgeometry comprised of two truncated ellipsoids, with a rule-based fiber distribution [2].We target the mapping of the template geometry onto patient-specific ultrasound scan-data. Mechanical simulations are performed within the IGA framework and will becoupled to electrophysiological simulations. The novelty of our research resides in theimplementation of IGA for a patient-specific electromechanical model that is based onscan-data. IGA is expected to reduce the computational effort when compared to thecurrently used methods in the literature while enabling an accurate representation of thedevelopment and behavior of VTs.REFERENCES[1] Hughes, T.J., Cottrell, J.A. and Bazilevs, Y., 2005. Isogeometric analysis: CAD, fi-nite elements, NURBS, exact geometry and mesh refinement.Comput. Methods Appl.Mech. Eng., 194, 4135–4195.[2] Rossi, S., Lassila, T., Ruiz-Baier, R., Sequeira, A. and Quarteroni, A., 2014. Ther-modynamically consistent orthotropic activation model capturing ventricular systolicwall thickening in cardiac electromechanics. Eur. J. Mech. A Solids, 48, 129-142.

NURBS-based isogeometric analysis of a bi-ventricular heart model

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NURBS-based isogeometric analysis of a bi-ventricular heart model

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