Introduction: Stressed people are physically, psychologically, and behaviorally damaged. This study aimed to investigate the effect of job stress on nurses' caring behaviors and quality of life related to their health during Coronavirus pandemic.Methods: The present study is an applied and analytical research conducted cross-sectionally in 2021. The study's statistical population was 740 nurses from the hospitals of Mazandaran University of Medical Sciences. The authors randomly selected a sample of 253 nurses using Cochran's formula. The data collection tool was a standard questionnaire. The structural equation model test analyzed the collected data to measure the research hypotheses using SPSS 22 and Amos 22 softwareResults: The standard coefficient value between stress and caring behavior is -0.47, and the significant value (t-value) is greater than 1.96 (equal to 5.350) at 95% level; therefore, the relationship between these two variables was found significant. Moreover, the standard coefficient value between job stress and quality of work life is -0.55, and the significant value (t-value) is greater than 1.96 (equal to 6.488) at the 95% level, showing a significant relationship between these two variables.Conclusion: Considering the obtained results, it is necessary to develop effective strategies, such as staff participation in decision-making, supervisory support, and reducing work pressure for improving working conditions and reducing nurses’ occupational stress
