In this study we surveyed families’ experiences with parental depression, stress, relationship conflict, and child behavioral issues during six months of the COVID-19 pandemic through the COVID-19: Global Social Trust and Mental Health Study. The current analyses used data collected from online surveys completed by adults in 66 countries from April 17, 2020-July 14, 2020 (Wave I), followed by surveys six months later at Wave II (October 17, 2020-January 31, 2021). Analyses were limited to 175 adult parents who reported living with at least one child under 18 years old at Wave I. Parents reported on children’s level of externalizing and internalizing behavior at Wave I. At Wave II, parents completed self-reported measures of stress, depression, and inter-partner conflict. Child externalizing behavior at Wave I significantly predicted higher levels of parental stress and marginally predicted parental depression at Wave II, controlling for covariates. Child internalizing behavior at Wave I did not predict parental stress or depression, controlling for covariates. Neither child externalizing nor internalizing behavior predicted parental relationship conflict. The overall findings demonstrate that child behavior likely influenced parental stress and depression during the COVID-19 pandemic. Findings suggest that mental health interventions for children and parents may improve the family system during times of disaster