The rate of sequestration of carbon, nitrogen and phosphorus by lentic ecosystems informs both the global carbon budget and the remediation of eutrophication. Here we estimate carbon, nitrogen and phosphorus burial in sediments of 34 lakes in Missouri, USA, and compare them to those found in other agricultural areas as well as to global estimates. Mean sediment accumulation rates varied by orders of magnitude among study regions, with the largest values (average 6 cm y-1) in impounded systems surrounded by intensive agriculture. Rates increased with the drainage ratio and decreased with the abundance of other surface water in the catchment (e.g., farm ponds). Average organic carbon burial differed by an order of magnitude among study regions (average 150-2100 g m-2 y-1) with differences related to the drainage ratio and eutrophication. Organic carbon burial was strongly correlated with burial rates of nitrogen and phosphorus. Comparisons with a diversity of global data show that many Midwestern USA impoundments have extremely high rates of biogeochemical burial likely due to the details of agricultural cropping systems, landscape configuration, and soil characteristics.</p