Noura A Almadni,1 Samira A Alsenany,2 Zeinab A Abusabeib,1 Hala K Ibrahim1 1Department of Community Health Nursing, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh, 11671 Saudi Arabia; 2Department of Public Health, Faculty of Nursing, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Samira A Alsenany, Faculty of Nursing, King Abdulaziz University, P.O. Box 22246, Jeddah, 4929, Saudi Arabia, Tel +966541368966, Fax +966016401000 Ex 3421, Email [email protected]: Having a weight problem can cause emotional distress, especially in students, who suffer from both issues at a high rate. As a result of the COVID-19 pandemic’s negative impact on society, these problems can be significantly impacted. The study aims to investigate the relationship between nursing students’ BMI and their mental well-being.Methods: A cross-sectional study was conducted on 423 students from the second through fourth baccalaureate years of Science of Nursing program – KSA. The instrument for the study was an online questionnaire distributed to the students via Google Forms during the academic year 2021– 2022 to collect data on the emotional state of students directly as a result of COVID-19 restrictions and limitations. The statistical analysis was carried out through Chi-square test was used to compare categorical data between groups and the Pearson coefficient is used to determine the correlation between two quantitative variables with normal distribution.Results: There is a significant correlation between BMI with depression score, anxiety score and stress score. Higher BMI indicated 6.4 times more likeliness to have depression than lower BMI (OR = 6.4). Students who had higher BMI were 2.7 times more likely to have anxiety than those who had lower BMI (OR = 2.7), and 9.4 times more likely to have stress than those who had lower BMI (OR = 9.4).Conclusion: Study findings indicate that nursing students’ BMI increases as depression, anxiety, and stress increase. During the COVID-19 pandemic, participants reported increased weight due to increased stress levels and increased eating. Students in nursing should be aware of the importance of adopting healthy habits and following a healthy lifestyle.Keywords: nursing students, BMI, emotional distress, COVID-19, pandemi