This study’s Part I proved that ground-motion duration could play an important role when assessing the nonlinear structural performance of case-study inelastic single degree-of-freedom systems. However, quantifying duration effects in many practical/more realistic engineering applications is not trivial, given the difficulties in decoupling duration from other ground-motion characteristics. This study’s Part II, introduced in this article, explores the impact of duration on nonlinear structural performance by numerically simulating the structural response of realistic case-study reinforced concrete bare and infilled building frames. Advanced computational models incorporating structural components’ cyclic and in-cycle strength and stiffness deterioration, and destabilizing (Formula presented.) effects are used. The proposed methodology relies on the generalized conditional intensity measure approach to select ground motions. This allows selecting records consistent with the seismic hazard at a target site, both in terms of spectral shape and duration. Those are employed as input to cloud-based nonlinear structural response analyses. Variance analysis is used to quantify the impact of duration on structural response. Furthermore, vector-valued fragility and vulnerability models alternatively using peak- and cumulative-based engineering demand parameters are derived. Results show that higher damage/loss estimates can be attained as ground-motion duration increases. Relative differences up to 44% are found in fragility median values for a pre-code reinforced concrete infilled frame when comparing scalar and vector-valued fragility models conditioned on average pseudo-spectral acceleration and significant durations up to 35 s
