Tuberculosis (TB) incidence in the UK remains high compared with other Western European countries. It disproportionately affects underserved groups, including homeless people, people in poor housing or affected by poverty, people with problem drug use, and people born in countries with a high incidence of TB. However, many cases are preventable with public health measures, and, when disease does occur, most people can be cured. This article summarises the updated recommendations on diagnosing, managing, and preventing TB from the National Institute for Health and Care Excellence (NICE). This guidance updates the 2011 clinical guideline and incorporates the public health guidance on the identification and management of TB in under-served groups