Poster presented at the Liposome Research Days 2014: Living Innovation, at the Technical University of Denmark, Copenhagen, 4-7 August 2014Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization.
Liposome formulations for topical application needs a vehicle to assure the desirable retention and adhesion of the drug-loaded liposomes onto the skin, and for this, hydrogels are regarded as promising systems. The hydrogel “soluble beta-glucan” (SBG) has caught our attention since it also promotes wound healing on its own.
Dual asymmetric centrifuge (DAC) utilizes a unique combination of two contra rotating movements of the sample-holder, which results in shear forces that efficiently homogenize and gives a size reduction of liposomes. We have investigated the use of DAC for both use in liposome size reduction and for further mixing of liposomes into hydrogels
