de Paoli, Frank

Enevoldsen, Johannes

Hovgaard, Henrik Lynge

Jeppesen, Anni Nørgaard

Juhl-Olsen, Peter

Jørgensen, Martin R.S.

Karaliunaite, Zidryne

Katballe, Niels

Kjaer, Daniel W.

Linnemann, Gerhard

Scheeren, Thomas W.L.

Vistisen, Simon

English

INTRODUCTION: Oesophagectomy is the mainstay of curative treatment for oesophageal cancer, but it is associated with a high risk of major complications. Goal-directed fluid therapy and individualised blood pressure management may prevent complications after surgery. Extending goal-directed fluid therapy after surgery and applying an individual blood pressure target may have substantial benefit in oesophagectomy. This is a protocol for a clinical trial implementing a novel haemodynamic protocol from the start of anaesthesia to the next day with the patient’s own night-time blood pressure as the lower threshold.METHODS: This is a single-centre, single-blind, randomised, clinical trial. Oesophagectomy patients are randomised 1:1 for either perioperative haemodynamic management according to a goal-directed fluid therapy protocol with an individual target blood pressure or for standard care. The primary endpoint is the total burden of morbidity and mortality assessed by the Comprehensive Complication Index 30 days after surgery. Secondary endpoints are complications, reoperations, fluid and vasopressor dosage and quality of life at 90 days after surgery.CONCLUSIONS: The results from this trial provide an objective and easy-to-follow algorithm for fluid administration, which may improve patient-centred outcomes in oesophagectomy patients.</p

ARTS repository - University of Groningen

Individualised perioperative blood pressure and fluid therapy in oesophagectomy:study protocol for a randomised clinical trial

https://pure.rug.nl/ws/files/745903922/A10220640_WEB.pdf

Individualised perioperative blood pressure and fluid therapy in oesophagectomy:study protocol for a randomised clinical trial

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ARTS repository - University of Groningen