The Proper Orthogonal Decomposition (POD) has been used for several years in the post-processing of highly-resolved Computational Fluid Dynamics (CFD) simulations. While the POD can provide valuable insights into the spatial-temporal behaviour of single transient flows, it can be challenging to evaluate and compare results when applied to multiple simulations. Therefore, we propose a workflow based on data-driven techniques, namely dimensionality reduction and clustering to extract knowledge from large simulation bundles from transient CFD simulations. We apply this workflow to investigate the flow around two cylinders that contain complex modal structures in the wake region. A special emphasis lies on the formulation of in-situ algorithms to compute the data-driven representations during run-time of the simulation. This can reduce the amount of data inand output and enables a simulation monitoring to reduce computational efforts. Finally, a classifier is trained to predict characteristic physical behaviour in the flow only based on the input parameters
