Structural optimization over the past decades matured from an academic theoretical field, to an important tool in the design procedure in various engineering disciplines. Some commercial software applications provide some suites with optimization solutions, but they are focused mostly in the aeronautics, automotive and aerospace industry. High Performance Optimization Computing Platform (HP-OCP) is a software developed by the ISAAR-NTUA and provides a holistic optimization approach for civil engineering structures. More precisely, HPOCP is a computational suite that has the ability to integrate with several structural analysis and design software and provide optimization solutions. Structural optimization is mainly divided in three groups, sizing (or parametric), shape and topology optimization. All of them are integrated in HP-OCP and the appropriate algorithms are provided in each category. Considering size and shape optimization, the parametric optimization module is developed, in which the design variables of the mathematical formulation can be the dimension of the section properties, the quality of the material, the coordinates of the nodes etc. In this module plenty of derivativebased and derivative-free algorithms are provided like the Projected Quasi-Newton, Constrained Optimization by Linear Approximation, Latin Hypercube Sampling etc. [1]. Considering the topology optimization module [2], the SIMP method is applied and the mathematical algorithms that are implemented are the Optimality Criteria and Method of Moving Asymptotes. HP-OCP was developed in C# programming language, making it a powerful suite that can be integrated with any commercial software that provide Application Programming Interface, batch analysis via XML files or any other type of data exchange format. In the current work the integration of HP-OCP with the SAP2000, ETABS and SCIA Engineering software is presented. Several examples considering parametric and topology optimization problems are examined. Remarkable cost reduction is succeeded in real-world structures, validating in this way the usefulness of HP-OCP not only in the research field but also in applied civil engineering problems