To determine the significance of compositional changes in amino acids in S proteins from different strains of CoVs, we compared changes between Rousettus bat coronavirus (GenBank: AOG30822.1) and hCoV/wuhan/WIV05/2019 strain using the hCoV-19 spike glycoprotein mutation surveillance dashboard, GISAID. We used GISAID data statistics to examine the amino acid changes in the S protein that increased the infectivity in emerging new variants.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV