Ahearn, Thomas U

Andrulis, Irene L

Anton-Culver, Hoda

Antonenkova, Natalia N

Arndt, Volker

Aronson, Kristan J

Augustinsson, Annelie

Baten, Adinda

Beane Freeman, Laura E

Becher, Heiko

Beckmann, Matthias W

Behrens, Sabine

Benitez, Javier

Bermisheva, Marina

Bogdanova, Natalia V

Bojesen, Stig E

Bolla, Manjeet K

Brauch, Hiltrud

Brenner, Hermann

Brucker, Sara Y

Burwinkel, Barbara

Campa, Daniele

Canzian, Federico

Castelao, Jose E

Chanock, Stephen J

Chenevix-Trench, Georgia

Clarke, Christine L

Conroy, Don M

Couch, Fergus J

Cox, Angela

Cross, Simon S

Czene, Kamila

Daly, Mary B

Dennis, Joe

Devilee, Peter

Dos-Santos-Silva, Isabel

Dwek, Miriam

Dörk, Thilo

Eccles, Diana M

Eliassen, A Heather

Engel, Christoph

Eriksson, Mikael

Evans, D Gareth

Jager, Agnes

Koppert, Linetta B

Kraft, Peter

Michailidou, Kyriaki

Neumeyer, Sonja

Park, Hanla A

Wang, Qin

English

BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk.METHODS: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy.RESULTS: Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 × 10-2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78-1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect.CONCLUSION: Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.</p

EUR Research Repository

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

https://pure.eur.nl/files/98429823/s41416-021-01432-8.pdf

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

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