AIM: Hyponatremia is the most common electrolyte disturbance among infections, especially with pneumonia. Here, we aimed to analyze the presence of hyponatremia among COVID-19 patients along with its relation to mortality.MATERIALS and METHODS: Patients were divided into two groups COVID-19 negative and positive and also another group with pneumonia and without pneumonia for covid-19 PCR positive patients. The association between hyponatremia and in-hospital mortality from any cause was evaluated with univariate and multivariate cox regression model.RESULTS: A total of 636 patients, a mean age of 50± 18 years, 48 % of the female with a median duration of hospitalization of 5.5 (IQR, 2,11) days were included. Of those 553 (%87) were detected COVID-19 PCR positive and 298 (47%) of those with pneumonia. The median serum sodium concentration was lower in COVID-19 PCR positive patients [134 (IQR, 130,137) mEq/L] compared to negatives [139 (IQR, 136, 140) mEq/L] (p<0.001). The median serum sodium levels were significantly lower in patients with pneumonia [136 (IQR, 133.138) mEq/L] than without pneumonia [139 (IQR, 137, 145) mEq/L] (p<0.001). All deaths occurred in patients with pneumonia [(n=40 (13.4 %)]. Patients with hyponatremia had increased mortality on unadjusted (OR, 3.85, 95%CI: 1.73, 8.53, P<0.001) and adjusted [OR, 3.58, 95%CI: 1.58, 8.1, P=0.002] in Cox proportional hazard modelsCONCLUSION: Hyponatremia at admission is prevalent and an independent risk factor for in-hospital mortality among COVID-19 patients particularly those with pneumonia. It might be an important laboratory clue for both the diagnosis and survive of these patients.</p
