Objective. To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in
humans. Methods. This comprehensive literature search comprised available English papers published in PubMed/Medline and
SCOPUS databases following the PRISMA-P guidelines and PICO/AXIS criteria. Results. Twenty-nine polymorphisms located
in 21 genes were identified as associated with SARS-CoV susceptibility/resistance, disease severity, and clinical outcomes
predominantly in Asian populations. Thus, genes implicated in key pathophysiological processes such as the mechanisms
related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. Conclusions.
Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are
associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have
important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized
translational clinical practice depending on the population studied and associated environments