Barta Anita

Rédei Dóra

Saidu Muhammad Bello

English

University of Szeged

4th Symposium of Young Researchers on Pharmacognosy  BOOK OF ABSTRACTS (ed. Judit Hohmann) Institute of Pharmacognosy, University of Szeged, Szeged, Hungary  22 24 May 2023  Venue: Szeged Regional Committee of Hungarian Academy of Sciences H-6720 Szeged, Somogyi u. 7, Szeged      https://us06web.zoom.us/j/89528815637?pwd=dHk1ODcyaXFIcWpRK0xnZXk1QU9tQT09 Meeting ID: 895 2881 5637, Passcode: 227572     doi: 10.14232/syrmpnpr.2023.af   University of Szeged, Faculty of Pharmacy, Institute of Pharmacognosy Szeged, 2023 4th Symposium of Young Researches on Pharmacognosy  22      Phytochemical investigations of Euphorbia desmondii    bellosaidu11@gmail.com  E. desmondii Keay & Milne-Redh. belongs to Euphorbiaceae family [1, 2]. It is native to West and Central African regions and has a height of up to 5.5 m [1, 3]. Together with its related species, E. kamerunica, they are used as village palisade to protect the communities from foreign invasion [2]. The aim of the present work was to isolate biologically active compounds from aerial parts of E. desmondii. Powdered plant material (1950 g) was extracted with methanol by percolation. Solvent-solvent partition of water-chloroform mixture gave the organic phase, which was subjected to open column chromatography on polyamide using step gradient elution with MeOH-water mixtures (20  100%), to yield five fractions. 60% MeOH fraction was subjected to a series of chromatographic techniques such as normal and reverse phase vacuum liquid chromatography, normal and reversed phase HPLC, PLC, and crystallization methods. Structures of isolated compounds were established using NMR and HRMS data. Phytochemical investigation of the 60% MeOH fraction afforded the isolation of 42 triterpenoid compounds. The triterpenoids were subdivided into three types (A, B and C) based on the presence or absence of keto group at C 7 and C 11 as shown on the figure below. 33 of the isolated compounds are new natural products.    TYPE A TYPE B TYPE C  References [1] Flora of West Tropical Africa, in Kew Bull. 1955: 139. [2] Annals of Missouri botanical gardens, 1994, 81: 376 [3] POWO (2023). "Plants of the World Online. Facilitated by the Royal Botanic Gardens, Kew. Published on the Internet; http://www.plantsoftheworldonline.org/ Acknowledgements The author would like to thank the financial support provided by the Ministry of Innovation and Technology of Hungary from NKFIH Fund, project no. TKP2021-EGA-32 and Stipendium Hungaricum Scholarship.   

Phytochemical investigations of Euphorbia desmondii : [abstract]

http://acta.bibl.u-szeged.hu/78896/1/syrpharmacognosy_2023_022.pdf

Phytochemical investigations of Euphorbia desmondii : [abstract]

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