Barta Anita

Hohmann Judit

Krstić Gordana

Mertha I. Gde

Spengler Gabriella

Wirasisya Dyke Gita

English

University of Szeged

4th Symposium of Young Researchers on Pharmacognosy  BOOK OF ABSTRACTS (ed. Judit Hohmann) Institute of Pharmacognosy, University of Szeged, Szeged, Hungary  22 24 May 2023  Venue: Szeged Regional Committee of Hungarian Academy of Sciences H-6720 Szeged, Somogyi u. 7, Szeged      https://us06web.zoom.us/j/89528815637?pwd=dHk1ODcyaXFIcWpRK0xnZXk1QU9tQT09 Meeting ID: 895 2881 5637, Passcode: 227572     doi: 10.14232/syrmpnpr.2023.af   University of Szeged, Faculty of Pharmacy, Institute of Pharmacognosy Szeged, 2023 4th Symposium of Young Researches on Pharmacognosy  20                   Plants of Euphorbiaceae has been traditionally used for medicinal purposes in many regions. The present study deals with thirty-two fractions prepared from 8 selected medicinal plants belonging to different genera of Euphorbiaceae based on their traditional medicinal information. The fractions were subjected to biological screening, including antimicrobial and anticancer assay. The antimicrobial activities were evaluated using standard disc diffusion method against thirteen bacteria (Gram-positive, Gram-negative) and four fungal strains, while the anticancer activity was tested on human colon adenocarcinoma cells by MTT assay. Chloroform and ethyl acetate fractions of Shirakiopsis indica demonstrated the highest antimicrobial activity against Candida glabrata ATCC 2001. The most sensitive strains were Candida parapsilosis and C. glabrata; at least one fraction of all species showed any activity against these fungi. Among the fractions, n-hexane and chloroform fractions of Euphorbia atoto exhibited strong antiproliferative activity against Colo 205 cell line with IC50 Mallotus rufidulus chloroform fraction showed the best activity against Colo 302 cell line (IC50  Euphorbia atoto was investigated for bioactive metabolites, and five compounds were isolated using various chromatographic techniques. Structure elucidation was performed by NMR and mass spectroscopic analysis.      

Investigation of antimicrobial and antitumor properties of selected Euphorbiaceae species : [abstract]

http://acta.bibl.u-szeged.hu/78894/1/syrpharmacognosy_2023_020.pdf

Investigation of antimicrobial and antitumor properties of selected Euphorbiaceae species : [abstract]

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