Abdullahi, Aminu S.

Ahmed, Luai A.

Al-Rifai, Rami H.

Almaskari, Fatima

Elbarazi, Iffat

Khan, Moien

Loney, Tom

Suliman, Abubaker

English

United Arab Emirates University: Scholarworks@UAEU / جامعة الامارات

National Center for Health Research November 2022      Changes in Hemoglobin Levels across Gestational Age among Pregnant Women in the United Arab Emirates: The Mutaba’ah Study  Aminu S. Abdullahi,1 Abubaker Suliman,1 Moien Khan,3 Iffat Elbarazi,1 Fatima Almaskari1,2 Tom Loney,4 Rami H. Al-Rifai,1,2 Luai A. Ahmed,1,2  1Institute of Public Health, College of Medicine and Health Sciences, UAE University, UAE 2Zayed Center for Health Sciences, UAE University, UAE 3Department of Family Medicine, College of Medicine and Health Sciences, UAE University, UAE 3College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, UAE  e-mail address of presenting author: aminutade@uaeu.ac.ae   Authors’ ORCIDs Aminu S. Abdullahi - 0000-0002-2639-631X Abubaker Suliman - 0000-0001-8906-3590 Moein Khan - ORCID:0000-0003-4970-4618 Luai A. Ahmed - 0000-0001-5292-8212 Iffat Elbarazi - 0000-0001-7151-2175 Fatima Almaskari - 0000-0001-6598-4942 Tom Loney - 0000-0003-1687-6587 Rami H. Al-Rifai - 0000-0001-6102-0353  Background: Iron deficiency anemia (IDA), as a result of low hemoglobin (Hb) level, is a leading cause of many adverse pregnancy outcomes. IDA and its longitudinal course and pattern among pregnant women in the United Arab Emirates (UAE) are not well understood. Aim: This study aims to estimate and characterize the hemoglobin level and its changing pattern across gestational periods, as well as identify factors associated with these changes among Emirati pregnant women. Materials and Methods: The analysis was performed using data from the ongoing Maternal and Child Health cohort study – The Mutaba’ah Study. All eligible women recruited in the study were included in this National Center for Health Research November 2022  analysis (N=1,120). KML machine learning algorithm was applied to identify distinct cluster trajectories of Hb measurements during pregnancy across two distinct periods of the 1st and the 3rd trimesters. Descriptive statistics were used to profile the study participants. Multinomial multivariable logistic regression was employed to identify risk factors for negative changes in Hb concentration. All analyses were performed using R software version 4.0.3 Results: The three identified clusters – A, B and C – had median Hb concentrations (g/L) of 123 [IQR = 118-128], 118 [IQR =114-123], and 104 [IQR=98 - 109] during the 1st trimester respectively (Figure 1). During the 3rd trimester, these values were 119 [IQR = 115 - 125], 100 [IQR = 93-105], and 108 [IQR = 102-113] respectively. Based on average Hb level changes, Clusters B and C saw a decrease and an increase in Hb level respectively, while Cluster A remained relatively stable within the normal range (≥110 g/L) during the 3rd trimester. A higher gravida (AOR=1.85, 95% CI=1.05-3.24, P<0.05) and being diabetic (AOR=3.39, 95% CI=1.19-9.62, P<0.05) were positively associated with a clinically significant decrease in Hb concentration; Being parous (AOR=0.50, 95% CI=0.28-0.88, P<0.05) and having a higher level of education (AOR=0.57, 95% CI=0.39-0.82, P<0.01) were negatively associated with a clinically significant decrease in Hb concentration (Table 1). Use of iron supplements before pregnancy (AOR=2.42, 95% CI=1.34-4.38, P<0.01), and a higher level of education (AOR=0.58, 95% CI=0.39-0.88, P<0.01) were positively and negatively associated with increasing Hb level respectively. With regards to IDA, 25.1% and 51.1% of the women had IDA during the 1st and the 3rd trimesters respectively. Most (68%) of those who were anemic during the 1st trimester remained so during the 3rd trimester. Conclusion: Majority of the women experienced IDA during pregnancy. Management of IDA among the women should be prioritized during the antenatal visits with particular attention to treatment adherence, women with higher gravida (>2), parous, diabetic and of lower education.   Keywords: Hemoglobin, Anemia, Mutaba’ah, Pregnant women, United Arab Emirates 

Changes in Hemoglobin Levels Across Gestational Age Among Pregnant Women in the United Arab Emirates: The Mutaba’ah Study

https://scholarworks.uaeu.ac.ae/cgi/viewcontent.cgi?article=1035&context=healthmed_research_conference

Changes in Hemoglobin Levels Across Gestational Age Among Pregnant Women in the United Arab Emirates: The Mutaba’ah Study

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United Arab Emirates University: Scholarworks@UAEU / جامعة الامارات