Arumuham, Atheeshaan

Gunn, Roger N.

Gupta, Susham

Howes, Oliver

Jauhar, Sameer

Mansur, Ayla

Mehrotra, Ravi

Natesan, Sridhar

Onwordi, Ellis Chika

Osugo, Martin

Rabiner, Eugenii A.

Reis Marques, Tiago

Shatalina, Ekaterina

Whitehurst, Thomas

English

Background: The synaptic hypothesis is an influential theory of the pathoaetiology of schizophrenia. Supporting this, there is lower uptake of the synaptic terminal density marker UCB-J in patients with chronic schizophrenia compared to controls. However, it is unclear whether these differences are present early in the illness. To address this, we investigated [11C]UCB-J volume of distribution (VT) in antipsychotic-naïve/free patients with schizophrenia (SCZ) recruited from first-episode services compared to healthy volunteers (HV). Methods: Forty-two volunteers (SCZ n = 21, HV n = 21) underwent [11C]UCB-J positron emission tomography to index [11C]UCB-J VT and distribution volume ratio (DVR) in the anterior cingulate, frontal, and dorsolateral prefrontal cortices, temporal, parietal and occipital lobes, hippocampus, thalamus and amygdala. Symptom severity was assessed in the SCZ group using the Positive and Negative Syndrome Scale (PANSS). Results: We found no significant effects of group on [11C]UCB-J VT or DVR in most regions of interest (effect sizes from d=0.0 to 0.7, p&gt;0.05), other than lower DVR in the temporal lobe (d=0.7, uncorrected 

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Synaptic Terminal Density Early in the Course of Schizophrenia: an in vivo UCB-J Positron Emission Tomographic Imaging Study of Synaptic Vesicle Glycoprotein 2A (SV2A)

https://kclpure.kcl.ac.uk/portal/files/219127142/ACCEPTED_ECO_SV2A_early_course_schizophrenia_19_May_2023.docx

Synaptic Terminal Density Early in the Course of Schizophrenia: an in vivo UCB-J Positron Emission Tomographic Imaging Study of Synaptic Vesicle Glycoprotein 2A (SV2A)

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