Background: Background: Congenital insensitivity to pain with
anhidrosis (CIPA) is characterized by recurrent episodes of infections
and unexplained fever, anhidrosis (inability to sweat), and absence of
reaction to noxious stimuli, self-mutilating behavior, mental
retardation and damages to oral structures. Case Presentation: In this
article, we have demonstrated the signs and symptoms of 4 children that
refer to the pediatrics department of the Imam Khomeini hospital and
assay about their complications with this disease. They mostly
presented by recurrent osteomyelitis in their feet that severely
controlled by antibiotic therapy and even surgery. They had no pain
sensation in spite of deep sore and infection. Conclusion: This
syndrome can be diagnosed by clinical and paraclinical tests together
but it would be better to confirm by genetic test. The diagnosis of
this syndrome helps us to try for the better quality of life for the
patients and avoid unnecessary amputations