An open clinical evaluation of siddha medicine Pippalyathi mathirai for Swasakasam (Bronchial asthma) was conducted from 2019 to 2022 in the Post Graduate Department of Maruthuvam in Govt. Siddha Medical College attached with Arignar Anna Govt. Hospital of Indian Medicine and Homeopathy, Chennai–106. A total of 40 cases were treated in Outpatient department. The clinical and Pathological assessment was carried out on the basis of Siddha and Modern aspects. All the patients were treated with Pippalyathi mathirai 1 tablet /bd after food for duration of 48 days. The responses were assessed once in 7 days for all the patients. The toxicological study revealed no toxicity was found in trial medicine Pippalyathi mathirai. The pharmacological study of Pippalyathi mathirai shows Bronchodilator activity in Milk Induced Leucocytosis in Mice. Most of the subjects were Male patients about 57.5 %. The peak incidence of Swasakasam was in the age group 40–60 years (17%) in both sexes. The patients occupation are working in Cement factories (7.5%), drivers (5%), farmers (7.5%), government staffs (10%), home makers (12.5%), hotel (10%), IT profession (5%), painters (7.5%), shop keepers (12.5%), students (7.5%), tailors (7.5%), teacher (2.5%), traffic police (5%). The prevalence was higher among the lower income group (48%) and middle income group (40%). Most of the patients have chronic history (82.5%). Majority of the patient follows mixed dietary habits (82.5%) Nearly 77.5 % have no relevant family history. Swasakasam is primarily due to the derangement of Iyyam and Vatha kutram. The study medicine Pippalyathi Mathirai has predominating kaarpu suvai and kaippu which neutralizes the deranged Iyya kutram. From the preclinical toxicity studies, the study revealed no toxicity and proved to be safe. From the pharmacological studies, it is evident that the study medicine Pippalyathi mathirai had Bronchodilator activity. No adverse effect was reported during the course of the treatment. The study medicine Pippalyathi mathirai reduces the frequency of wheeze attacks and gave maximum relief from the symptoms of Swasakasam. The study medicine Pippalyathi mathirai shows good improvement in Peak Expiratory Flow Rate. Therefore the author conclude that, the study medicine Pippalyathi mathirai could be a better solution for Swasakasam (Asthma)
