Intra- and intercellular mitochondrial dynamics and communication: therapeutic implications for mitochondrial-based medicine

Abstract

Mitochondria and their derivatives participate in health-disease processes and are therefore susceptible to be used as therapeutic targets due to their extensive communication capacity and impact at both intra- and intercellular levels.At the intracellular level, fusion/fission can signal different events in the pathogenesis of chronic non-communicable diseases (NCD). Likewise, mitochondria obtain information from the environment (UPR response, MAMs) and communicate with other organelles of the cell.At the intercellular level, they transport diverse information in extracellular vesicles to nearby cells, although they also have systemic reach and can be directed to other targets or tissues through the bloodstream.The authors would like to thank Carlos Saldaña for his help with the design and visualization of this figure.</p