In the last two decades, ICT use in schools grew exponentially. In this paper, the relationship between ICT and school’s efficiency and the mechanisms through which ICT can enhance schools’ productivity are investigated, using PISA 2018 data for about 5400 schools. Empirically, we analyze school’s efficiency in producing ICT-mediated instructional time as well as final educational output, by implementing a network Data Envelopment Analysis (DEA) model. The analysis is complemented by a conditional DEA to account for the presence of possible external drivers of schools’ efficiency. Results show that the average schools’ efficiency in using ICT is relatively low, and that it is mainly driven by the ability of translating ICT-mediated instructional time into learning, rather than by the amount of ICT and human resources. This evidence is consistent across countries. By investigating the role of ICT in schools’ efficiency the paper provides insights to guide the transition of digital technology into learning