The aim of the study, which was conducted as a clinical prospective
study, was to determine the effectiveness of basic periodontal therapy,
local application of probiotics, active oxygen and clindamycin gel after
basic periodontal disease therapy in subjects with chronic periodontitis.
Different approaches to the treatment of chronic periodontitis have
been compared. In addition to basic (causal) therapy, which is the "gold
standard" in the treatment of chronic periodontitis, probiotic, active
oxygen and clindamycin gel therapy was used.
All subjects underwent a detailed clinical examination and accurate
anamnestic data were taken. The dental examination revealed a chronic
form of periodontitis in all subjects, which was confirmed by
radiological examination. Clinical parameters were determined before
therapy, on the seventh day and 30 days after therapy. Subgingival
specimens were collected before basic therapy and after 30 days to
identify the following bacterial species: Aggregatibacter
actinomycetemcomitans, Porphyromonas gingivalis, Prevotella
intermedia, Tannerella forsythensis and Treponema denticola. The
results were compared by clinical examination (oral hygiene indices,
gingival and periodontal index) and polymerase chain reaction (PCR)
by the method for testing periodontopathogenic bacteria.
The study involved 160 respondents divided into 4 groups. The first
group consisted of 40 subjects with chronic periodontitis who received
only basic therapy (control group). The second group consisted of 40
subjects with chronic periodontitis who were treated with probiotic
bacteria, Probiotic® (Ivančić and sons, Hemofarm Stada group, Vršac)
in the periodontal pocket for 5 days.
The third group consisted of 40 subjects with chronic periodontitis
who, after basic therapy, received active oxygen therapy in liquid form
(Deverra, Farm DOO, Lebane) in the periodontal pocket for 5 days.
The fourth group of subjects, a total of 40, with a chronic form of
periodontitis, received basic periodontal therapy, after which
clindamycin gel (clindamycin hydrochloride gel 2%) was applied
topically to the periodontal pocket, once.
The clinical trial showed better results in groups II, III and IV
compared to the first control group of subjects in whom only basic
periodontal therapy was used. After therapy, a reduction in the presence
of the following bacterial species was found: Aggregatibacter
actinomycetemcomitans, Porphyromonas gingivalis, Prevotella
intermedia, Tannerella forsythensis and Treponema denticola (p
<0.001). Based on this clinical trial, it can be concluded that the
combined basic therapy and local application of probiotics and active
oxygen gave better results compared to the control group in which only
basic therapy was used
