The preparation, starting from glucose, of 3'-[ (2-chlorophenoxy)phosphinylmethyl]-
N2-isobutyryl-5'-0-(4-methoxytrityl)-2' ,3'-dideoxyguanosine ts
described. Applying established phosphotriester methods, 21 was used to synthesize
a phosphonate analogue of the dinucleotide monophosphate d(G-C)