Ovarian cancer is the deadliest of gynecological malignancies, and despite the efforts to improve existing treatment methods and early diagnosis, no progress has been made. Endometrial carcinoma (EC) is the fourth most common malignancy in women. The p53 gene has a leading role in the control of the cell cycle and the initiation of carcinogenesis. The p53 protein induces apoptosis, or cell cycle arrest, which allows the cell to repair genomic damage. Loss of p53 function plays a central role in the development of malignant tumors. P53 is a tumor suppressor gene whose expression in tumors is associated with progression and poor prognosis. Ki67 protein is a cell proliferation marker. Immunohistochemical staining with Ki-67 provides reliable data on the growth fraction of tumors. The Ki67 marker reflects cell proliferation in the tissue being examined. By reading the immunohistochemical expression of Ki67, we can obtain information about the proliferative index and about the growth fraction of tumors. The number of Ki67 positive tumor cells often correlates with the clinical course
