PELC is a Python package designed to calculate efficiently the HLA Eplet Load (based on the EpRegistry database) between donors and recipients. v0.5.4 includes the latest version of EpRegistry (V2023-08-25).If you use this software, please cite it as below. Lhotte, R., Clichet, V., Usureau, C. & Taupin, J. (2022). Python Eplet Load Calculator (PELC) package (Version 0.5.4.1) [Computer software]. https://doi.org/10.5281/zenodo.725480