Acute Toxicosis of selenium and monensin produced a significant increase in uro- and corpoporphyrin levels. Results also indicated that acute lead toxicosis increased liver porphyrins levels of broiler chickens. This was further aggravated when selenium or monensin were administrated concurrently. This experiment indicated presence of an interaction between lead and selenium or monensin in elevation of porphyrins in the liver tissue of the broiler chickens