Immunogenicity of a Two Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.

Atmar, Robert L; Babu, Tara M; Baden, Lindsey R; Beigel, John H; Branche, Angela R; Bäcker, Martín; Crandon, Sonja; Diemert, David J; Falsey, Ann R; Frey, Sharon E; Fusco, Dahlene N; Goepfert, Paul A; Immergluck, Lilly C; Jackson, Lisa A; Kamidani, Satoshi; Kottkamp, Angelica C; Little, Susan J; Losada, Cecilia; Luetkemeyer, Anne F; Mahgoub, Siham M; Makhene, Mamodikoe K; Makowski, Mat; McQuarrie, Lisa J; Montefiori, David C; Mu, Jinjian; Netzl, Antonia; Novak, Richard M; Posavad, Christine M; Presti, Rachel M; Roberts, Paul C; Rouphael, Nadine G; Rupp, Richard; Smith, Derek J; Telu, Kalyani; Walter, Emmanuel B; Whitaker, Jennifer A; Winokur, Patricia L

Immunogenicity of a Two Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.

Abstract

We compared the serologic responses of one versus two doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A two-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost

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