Additional file 1: Figure S1. Confirmation of amyloid fibril purification. Figure S2. Aβ38 peptides are present in high abundance in human and mouse fibrils. Figure S3. Effect of Aβ38, Aβ40, and Aβ42 peptides on Aβ38 and Aβ40 amyloid fibril formation in vitro. Figure S4. Comprehensive MS analysis of purified mouse and human fibrils. Figure S5. In vitro and in vivo validation of proteomics data. Figure S6. Metallothionein-3, a metal-binding protein affects amyloid aggregation. Figure S7. Fly orthologues of MS-identified candidate proteins modulate Aβ42-induced neurotoxicity in vivo