The Cislunar region is becoming a focal point of expansion over upcoming decades. Long-term Lunar infrastructure supporting Cislunar expansion must be located in key regions on the Moon\u27s surface and in space. The purpose of this research is to identify key regions of interest on and around the Moon by investigating the location of valuable resources and the destination of future missions. Once key regions are established, low-lunar orbit trajectories are analyzed to enable methods of passive information gain in identified key regions of interest. It has been found that the South Pole and Earth-sided craters are key regions on the Lunar surface in the near future. Furthermore, an analysis of low lunar orbit trajectories is completed and demonstrates a possible framework to service the South Pole region
