Affolter, Hannah

English

St. Catherine University

St. Catherine University SOPHIA Antonian Scholars Honors Program School of Humanities, Arts and Sciences 5-2023 Multiple System Atrophy: Bridging the Gap Between Science and Humanities Hannah Affolter Follow this and additional works at: https://sophia.stkate.edu/shas_honors  Part of the Arts and Humanities Commons Multiple System Atrophy Bridging the gap between science and humanities  Hannah AffolterCONTENT01 Topic Choice 02 Background03 Science and humanities04 Poetry and ArtINTRODUCTIONMSA is a progressive neurodegenerative disease with symptoms resulting from the loss of function of nerve cells located in the central nervous system.MSACause● Risk factor: SCNA gene● Increased amounts of alpha-synuclein in neurons● Risk factor: COQ2 gene● CoQ2 → COQ10● Environmental factorsMSASymptoms● Stiffness● Ataxia● Swallowing ● Speech● Bladder control● Hypotension2 typesParkinsonian: Most commonCerebellar: Associated with the cerebellum MSADiagnosis● Neurological Exam● MRI/ PET scan● Dopamine Assessment● Levodopa● Lifespan: 7 years after diagnosis MSATreatment● Ataxia: Levodopa, Physical therapy, Occupational therapy● Swallowing: Feeding tube● Speech: Speech therapy● Bladder control: Anticholinergic drugs● Orthostatic Hypotension: Increased water and salt intake, Medication, Compression stockingsMSAClinical Trials● 14 studies at the Mayo Clinic○ Stem cell○ Sex specific hormone factors○ Rifampicin○ BiomarkersReferencesWenning, G. K., Colosimo, C., Geser, F., & Poewe, W. (2004). Multiple System Atrophy. The Lancet Neurology, 3(2), 93–103. https://doi.org/https://doi.org/10.1016/S1474-4422(03)00662-8 Mayo Clinic. (2022). Multiple system atrophy (MSA). Mayo Foundation for Medical Education and Research. Retrieved April 3, 2023, from https://www.mayoclinic.org/diseases-conditions/multiple-system-atrophy/symptoms-causes/syc-20356153Multiple System Atrophy (MSA). (n.d.). What is multiple system atrophy?: MSA Symptoms & Treatment. Multiple System Atrophy Coalition. Retrieved April 3, 2023, from https://www.multiplesystematrophy.org/about-msa/ U.S. Department of Health and Human Services. (2023). Multiple system atrophy. National Institute of Neurological Disorders and Stroke. Retrieved April 3, 2023, from https://www.ninds.nih.gov/health-information/disorders/multiple-system-atrophy Cleveland Clinic. (2022). Multiple system atrophy (MSA): Symptoms & treatment. Retrieved April 3, 2023, from https://my.clevelandclinic.org/health/diseases/17250-multiple-system-atrophy MedlinePlus. (2016). Multiple system atrophy. Retrieved April 18, 2023, from https://medlineplus.gov/genetics/condition/multiple-system-atrophy/#causesMultiple System Atrophy (MSA) Clinical Trials - Mayo Clinic Research. (2019). Clinical Trials. Retrieved April 18, 2023, from https://www.mayo.edu/research/clinical-trials/diseases-conditions/multiple-system-atrophy-(msa) Emotion

Multiple System Atrophy: Bridging the Gap Between Science and Humanities

https://sophia.stkate.edu/cgi/viewcontent.cgi?article=1077&context=shas_honors

Multiple System Atrophy: Bridging the Gap Between Science and Humanities

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