Anti-hyperlipidemic Activity of Carissa carandas (Auct.) Leaves Extract in Egg Yolk Induced Hyperlipidemic Rats

Abstract

The  Purpose  of  this  study  was  to  examine  the  lipid  lowering  activity  of  aqueous:  ethanol  (1:1)  extract  of Carissa  carandas  in  Egg  yolk  induced  hyperlipidemic  rats.  A  highly  significant  increase  in  the  weight  of  group C (High cholesterol  diet)  rats  was  observed  when  compared  with  control  group N (P<0.01).  The  extract  caused  a  significant reduction  in  body  weight,  Cholesterol,  Triglycerides,  HDL  and  LDL  in  hyperlipidemic  rats.  Histopathological  changes induced by  high cholesterol diet were  also significantly reduced by the  extract. The  activity of  ethanol  and water extract of C. carandas was comparable to that of atorvastatin