Today is the era of condense competition among the industry globally. To achieve a strategic edge over their competitors, organizations move beyond the traditional boundaries of operations and demand for more and effective productive work from their employees. This results in increased workload and generates a demanding and stressful working environment. Moreover, the study aimed to investigate the effect of workplace stress and heavy workload on employee performance and their turnover intentions from the organization. A survey questionnaire was used to gather data from the employees of pharmaceutical companies in Khyber Pakhtunkhwa. Based on 292 participants’ responses from 570 employees. The study's findings revealed that there is a significant and negative relationship between workplace stress and heavy workload with employees ’ performance, and also a positive relationship between workplace stress and heavy workload with employee turnover intention, but Work Stress and Heavy Workload have really no effect on TI. Based on the current findings of the research, it has been concluded that the management of Pakistani pharmaceutical companies must introduce better tools to reduce workplace stress and workload. This will not only enhance organizational work performance but will minimize overall anxiety and stress, lowering the likelihood of employees leaving the company.
 
