Wpływ wybranych leków hipotensyjnych na biodostępność składników mineralnych z grochu łuskanego w procesie trawienia enzymatycznego in vitro

Abstract

Interaction of antihypertensive drugs with minerals can occur during digestion in the digestive tract of patients. The aim of this study was to estimate the influence of hypotensive drugs on the bioavailability of magnesium, iron, zinc and copper from shelled pea during in vitro enzymatic digestion. The degree of release of magnesium, iron, zinc and copper from shelled pea was determined with and without (the control) addition of hypotensive drugs. Four antihypertensive drugs in standard doses (one tablet per sample) were analysed: Metocard (β-blocker), Cardilopin (Ca-antagonist), Apo-perindox (angiotensin-converting-enzyme inhibitor ACE-I) and Indapen (diuretic). The samples were subjected to enzymatic digestion under in vitro conditions. The content of minerals in shelled pea before and after enzymatic digestion was determined by flame atomic absorption spectrometry (AAS). It was found that Indapen (indapamide) significantly decreased the release of magnesium, iron and zinc from shelled pea. The degree of release of magnesium was lower in samples with Metocard (metoprolol) than in the control. The release of copper was significantly reduced by Cardilopin (amlodipine). Indapamide, metoprolol and amlodypine decreased the release of minerals from pea in vitro enzymatic digestion of shelled pea