The importance of serum hepatocyte growth factor concentration in prehypertension

Abstract

Istraživanje „Endemska nefropatija u Hrvatskoj – epidemiologija, etiologija i patofiziologija” provodila se u okolici Slavonskoga Broda tijekom 7 godina. Ispitanici su bili praćeni 5 ili 7 godina, ovisno o godini kada su uključeni u istraživanje. U ovo istraživanje uključene su osobe iz endemskih sela bez endemske nefropatije te stanovnici neendemskih sela. Ukupno 880 ispitanika (57,8 % žena i 42,2 % muškaraca) podijeljeno je prema arterijskomu tlaku (AT) u tri skupine. 295 ispitanika (33,5 %) klasificirano je u skupinu s optimalnim arterijskim tlakom (OAT), 317 ispitanika (36 %) kao predhipertoničari (PHT), a 268 ispitanika (30,5 %) kao neliječeni hipertoničari (HT). Učinjen je fizikalni pregled, uzeta opsežna anamneza te prikupljeni uzorci krvi i urina za laboratorijske pretrage. Arterijski tlak i srčana frekvencija mjereni su šest puta tlakomjerom OMRON. Ispitanici s OAT-om su najmlađi, PHT su značajno stariji, dok su najstariji HT. PHT ispitanici također imaju veću tjelesnu masu, opseg struka, indeks tjelesne mase (BMI), serumsku glukozu, ukupni kolesterol i razinu triglicerida u usporedbi s OAT-om. U skupini PHT uočeno je značajno više osoba s metaboličkim sindromom u odnosu na OAT. Nije nađena statistički značajna razlika u serumskoj koncentraciji čimbenika rasta hepatocita (HGF) među skupinama, iako postoji trend porasta koncentracije HGF-a s rastom AT-a. Nađena je značajna pozitivna korelacija između vrijednosti sistoličkoga i dijastoličkoga AT-a s koncentracijom HGF-a za sve ispitanike te u skupini predhipertoničara. Postoji značajna pozitivna korelacija između vrijednosti HGF-a i TGF-a bete za sve ispitanike te značajna korelacija za HGF i albuminuriju za sve ispitanike. Nije nađena značajna razlika za koncentraciju HGF-a u odnosu na prisutnost metaboličkoga sindroma. U multivarijantnoj linearnoj regresijskoj analizi su sistolički tlak i koncentracija HGF-a bili nezavisni prediktori albuminurije, a dob i TGF-beta nezavisni prediktori porasta koncentracije HGF-a. Na kraju praćenja značajno je više ispitanika razvilo arterijsku hipertenziju u skupini PHT u odnosu na OAT.The study "Endemic Nephropathy in Croatia - Epidemiology, Etiology and Pathophysiology" was conducted in the villages near Slavonski Brod throughout a period of seven years. Subjects were divided into three groups according to the value of their blood pressure (BP): 295 subjects (33.5 %) were classified into the group with optimal blood pressure (OAT), 317 subjects (36 %) were classified as prehypertensive (PHT), and 268 subjects (30.5 %) as untreated hypertensives (HT). All subjects underwent a physical examination, and provided blood and urine samples for laboratory tests. Blood pressure and heart rate were measured six times with an OMRON device using appropriate cuff size. Mean values were used for analysis. Subjects with the OAT were the youngest, the PHTs are significantly older, and the HTs were the oldest. Subjects with the PHT also had significantly higher body weight, waist circumference, BMI, fasting serum glucose, total cholesterol, and triglyceride levels compared to the OATs. There was significantly higher number of subjects with the metabolic syndrome in the PHT group than in the OAT group. There were no significant differences between the concentration of the HGFin the PHT and HT groups compared to the OAT group. A significantly positive correlation was found between systolic and diastolic blood pressure values and HGF concentration for all subjects. The correlation was higher for diastolic AT. There was a significantly positive correlation between HGF and TGF beta values for all subjects, while there was no significant difference between the HGF concentration and blood leukocyte count or CRP. There was also a significant correlation between HGF and albuminuria for all subjects. No significant difference was found in HGF concentration in relation to the presence of metabolic syndrome in all subjects Multivariant linear regression showed that systolic BP and HGF concentration are independent predictors of albuminuria elevation, whereas age and TGF beta are independent predictors of HGF concentration elevation. At the end of the seven- or five-year follow-up, significantly higher number of subjects developed arterial hypertension in the PHT group compared to the OAT group