van der Sande, Emilie

English

Functional validation of candidate genes of myopia (nearsightedness) in mouse models, and the exploration of high dose atropine eye drops for the treatment of Mendelian myopia in children and mice

EUR Research Repository

Propositions belonging to the thesis Functional Myopia Studies in Mice Emilie van der Sande  1. The inverse relation between baseline axial length and axial length growth during postnatal development allows accurate prediction of eye growth, which improves the reference for experimental myopia induction in mice. This thesis 2. Global knockout of a gene in mice can cause systemic effects, which could hamper making inferences on ocular consequences. This thesis 3. Knockout of the first identified gene for common myopia, Gjd2, prevents myopia in a mouse model highly responsive to myopic triggers. This thesis 4. High dose atropine reduces axial elongation even in myopia with a strong genetic driver. This thesis 5. The eye size, retinal architecture, and nocturnal nature make the mouse a challenging model to study myopia. This thesis 6. Although knockout of candidate genes may not reveal an ocular phenotype in mice, this does not exclude a functional role in myopiagenesis.  7. Programming in MATLAB can be time consuming and time efficient at the same time. 8. In theory, there is no difference between theory and practice. But, in practice, there is. Jan L. A. van de Snepscheut 9. Standards are needed to minimize carbon footprint in laboratory-based research. 10. Doing a PhD is like running a marathon. 11. The best way out is always through. Robert Frost 

Functional myopia studies in mice

https://pure.eur.nl/files/88062347/thesisstellingenv2_64365af363916.pdf

Functional myopia studies in mice

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