Universidad de Murcia. Departamento de Biología Celular e Histología
Doi
Abstract
Eccrine spiradenoma is a rare lesion
originating from eccrine sweat glands, with only few
cases reported in breast tissue: we here describe for the
first time, an eccrine spiradenoma arising in the nipple.
An 84 year-old woman with a lesion enlarging her right
nipple, showing ulcerations and eczema-like changes of
the covering skin, was admitted to our hospital. Surgical
excision of the central quadrant with nipple-areola
complex was performed, followed by histopathological
evaluation which revealed an adenoma with
predominantly basaloid epithelial cells. The lesion was
composed of tightly packed small and large groups of
cells, arranged in diffuse alveolar/pseudorosette
formations. The small cells expressed p63 and calponin,
while a positive expression of CK7 and CD117 was
detected in large cells. After careful and detailed
examination, excluding various similar entities, a
diagnosis of eccrine spiradenoma has been rendered.
Although extremely rare, eccrine spiradenoma
should be taken into account in the differential diagnosis
of subcutaneous primary breast tumors