Universidad de Murcia. Departamento de Biología Celular e Histología
Abstract
Leukemias, a heterogeneous group of
hematological disorders, are characterized by ineffective
hematopoiesis and morphologic abnormalities of
hematopoietic cells. Thrombocytopenia is a common
problem among leukemia types that can lead to
hemorrhagic complications in patients. The purpose of
this review article is to identify the conditions associated
with the incidence of thrombocytopenia in leukemias. It
can be stated that although translocations have been
considered responsible for this complication in many
studies, other factors such as bone marrow failure, genes
polymorphism, a mutation in some transcription factors,
and the adverse effects of treatment could be associated
with pathogenesis and poor prognosis of
thrombocytopenia in leukemias. Considering the
importance of thrombocytopenia in leukemias, it is
hoped that the recognition of risk factors increasing the
incidence of this complication in leukemic patients
would be useful for prevention and treatment of this
disorder