Universidad de Murcia. Departamento de Biología Celular e Histología
Abstract
Myocardial infarction (MI) is a lifethreatening disease. The expression of Smad proteins in
the ischemic myocardium changes significantly
following myocardial infarction, suggesting a close
relationship between Smad proteins and heart
remodeling. Moreover, it is known that the expression of
Smads is regulated by transforming growth factor-β
(TGF-β) and bone morphogenetic proteins (BMP).
Based on these findings, regulating the expression of
Smad proteins by targeting TGF-β and BMP in the
ischemic myocardium may be considered to be a
possible therapeutic strategy for the treatment of
myocardial infarctio