Universidad de Murcia. Departamento de Biología Celular e Histología
Abstract
Telocytes (TCs) represent a new distinct type
of interstitial cells found in many organs, including
lungs. TCs are mainly defined by a small cellular body
from which arise very long (hundreds of micrometers)
extensions named telopodes. During the last years, TCs
were characterized in respect with their microRNA
profiles, gene features and proteome signatures. Also,
the ultrastructural 3D configuration was further
elucidated by the aid of the FIB-SEM technology. TCs
are able to communicate by homo- and heterocellular
contacts with neighboring cells and are also able to
transfer genetic information and signaling molecules to
influence other cells by means of extracellular vesicle
release. However, the exact function of lung TCs
remains unclear. Here, we review the potential
significance of TCs in the pathogenesis of pulmonary
diseases. We will also discuss some future possibilities
for targeting TCs as a potential therapeutic strategy