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Current and emerging treatment modalities for Leber’s hereditary optic neuropathy: a review of the literature
Authors
Anna Theodorou-Kanakari Karampitianis, Spyridon Karageorgou, Vasiliki Kampourelli, Eleni Kapasakis, Efstathios Theodossiadis, Panagiotis Chatziralli, Irini
Publication date
1 January 2018
Publisher
Abstract
Introduction: The purpose of this review is to present the current and emerging treatment alternatives for Leber’s hereditary optic neuropathy (LHON), emphasizing the most recent use of idebenone and stem cells or gene therapy. Methods: A comprehensive literature review was performed at the PubMed database regarding the various treatment modalities for LHON. Results: Treatment modalities for LHON include nutritional supplements, activators of mitochondrial biogenesis, brimonidine, and symptomatic and supportive treatment, but nowadays attention is being paid to idebenone and gene therapy or stem cells. Conclusion: The treatment of LHON remains challenging, given the nature of the disease and its prognosis. © 2018, The Author(s)
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Pergamos : Unified Institutional Repository / Digital Library Platform of the National and Kapodistrian University of Athens
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oai:lib.uoa.gr:uoadl:2939729
Last time updated on 10/02/2023
Pergamos : Unified Institutional Repository / Digital Library Platform of the National and Kapodistrian University of Athens
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:lib.uoa.gr:uoadl:3107022
Last time updated on 10/02/2023