Lab-on-a-chip for Isolating Circulating Adipose Stromal Cells: Pre-processing Module

Abstract

International audienceCirculating Adipose-derived Stromal Cells (ASC) can be considered as biomarkers of type II diabetes as recent research shows. However isolating ASC from whole blood is a difficult task, since no unique specific marker is assigned to these cells. They also have a wide size-distribution, hence a preconcentration step has to be done in order to completely isolate them. In this work, we demonstrate an ASC preconcentration module based on hydrodynamic filtration in a lab on a chip configuration (LOC)